N-Formylmaleamic acid: An intermediate in nicotinic acid metabolism
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چکیده
منابع مشابه
N-Formylmaleamic acid: an intermediate in nicotinic acid metabolism.
Jiménez et al. (1) have published a thorough and impressive analysis of the genetic determinants of aerobic nicotinic acid degradation in Pseudomonas putida. The chemistry of this pathway has been known for some time (2) with the exception of the formation and hydrolysis of the (up to now) putative intermediate, N-formylmaleamic acid. These gaps were due to (i) difficulties in the synthesis of ...
متن کاملNicotinic Acid Metabolism
Previous reports from this laboratory have described the isolation of 6-hydroxynicotinic acid and 6-0x0-1 ,4,5,6-tetrahydronicotinic acid from the reaction media of a clostridial species grown on nicotinic acid (1). Bn enzyme that catalyzes the reversible oxidation of nicotinic acid to HNA’ has been purified from extracts of this microorganism (2). Since fortified crude extract of this Clostrid...
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6-Hydroxynicotinic acid was demonstrated to be the first intermediate in the degradation of nicotinic acid by a clostridium. In the presence of pyruvate, other intermediates accumulated; two of these were identified, one as 1,4,5,6tetrahydro-6-oxonicotinic acid, and the other as a!-methyleneglutaric acid. The pathways for nicotinic acid degradation may be considered as involving successive oxid...
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An enzyme that catalyzes the reversible hpdroxylation of nicotinic acid to 6-hydroxynicotinic acid has been purified from extracts of a nicotinic acid-fermenting clostridium. The enzyme appears to be a flavin adenine dinucleotidecontaining non-heme iron protein and utilizes triphosphopyridine nucleotide as the ultimate electron acceptor. The purified enzyme also exhibits reduced triphosphopyrid...
متن کاملNicotinic acid and nicotinamide metabolism in ascites cells in vitro.
The studies reported here are primarily concerned with the metabolism of vitamin-containing nucleotides in intact cells. Holzer, Friedrich, and Grisebach (I) have reported that the Ehrlich ascites cells incorporated nicotinic acid-C4 slowly into nicotinamide adenine dinucleotide. Since, under the same conditions, nicotinamide-Cl4 was rapidly incorporated into nicotinamide adenine dinucleotide, ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2008
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0808695105